�Researchers at the NYU Cancer Institute and the Ronald O. Perelman Department of Dermatology have identified mebendazole, a drug victimised globally to treat parasitic infections, as a novel investigational agent for the treatment of chemotherapy-resistant malignant melanoma.
Because most patients with metastatic melanoma fail to reply to available therapies, the discovery of a viable investigational discourse with an established safety device profile could address a serious unmet need in oncology. Effectively sidestepping the prohibitive costs and long lead times typically required to find new crab medicines, the NYU squad screened a library of already approved drugs for activity against the most deadly form of skin cancer.
Their report, which was selected for advance online publication by Molecular Cancer Research, is published in the August issue of the journal. Since submitting the article for publication, the authors have conducted additional pre-clinical studies of mebendazole in an in vivo model of chemotherapy-resistant malignant melanoma and ar now preparing a phase I clinical trial, expected to commence next year at NYU Cancer Institute.
"While rational drug design remains a perfectly valid way to develop crab therapies, we also motivation approaches that are less costly and more productive of new effective treatments," said trail author Seth J. Orlow, M.D. Ph.D., Chair of the Ronald O. Perelman Department of Dermatology at New York University School of Medicine. "You could say this is more of a guerrilla advance. Instead of screening millions of untested compounds for an agent that inhibits or stimulates a particular molecular target area, we chose to screen a prominent library of already approved drugs for novel activity against melanoma cells, and then raise the most promising campaigner rapidly to clinical
Friday, 15 August 2008
Thursday, 7 August 2008
Lindsay Lohan - Lohan Fumes Over Police Chiefs Comments
LATEST: LINDSAY LOHAN has hit back a Los Angeles police chief wHO accused her of courtship publicity from the paparazzi by behaving badly, stigmatization his comments "inappropriate".
Los Angeles police head William Bratton claimed photographers have calmed down since "Britney started wearing clothes (and) Lindsay Lohan has gone cheery", referring to the actress' rumoured latinian language with DJ Samantha Ronson.
But Lohan is fuming over his comments and told him to "mind your possess f**king business".
She tells celebrity website TMZ.com, "Police chiefs shouldn't get involved in everybody else's business or their personal lives. It's inappropriate."
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Friday, 27 June 2008
Days Of Our Lives - Sweeney Expecting Baby
DAYS OF OUR LIVES actress ALISON SWEENEY is pregnant with her second child.
The 31-year-old soap star revealed the news on U.S. reality diet show The Biggest Loser, which she hosts, during filming on Monday (23Jun08).
Describing the moment to People.com, her representative Carrie Simmons says, "She told them that, in a season all about family, hers is about to get bigger."
Sweeney and her husband Dave Sanov are already parents to son Ben, three.
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Sunday, 22 June 2008
Justin Timberlake - Timberlake Credits Diaz Romance For Teaching Him Most About Women
Pop superstar JUSTIN TIMBERLAKE is grateful to his ex-girlfriend CAMERON DIAZ for teaching him how to put life into perspective.
The SexyBack hitmaker admits he is still confused by the fairer sex, despite having dated some of the world's most famous women, including Britney Spears and his current beau Jessica Biel.
But he credits Charlie's Angels beauty Diaz - who he split from in January 2007 after almost four years together - for helping him to figure out more about the female form.
He tells Britain's Cosmopolitan magazine, "I know a couple more things than I used to, but us men will never understand women. Ever!
"I think I learnt a lot from my relationship with Cameron, notably that you should always put things in perspective. As much as I've learnt though, I'm still a man, so I have some kind of learning disability. And women wouldn't have us any other way."
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Saturday, 14 June 2008
Downloading case in the High Court
Four record companies have brought a High Court action to compel Eircom - the State's largest broadband service provider - to prevent its networks being used for the illegal downloading of music.
It's the first case to be aimed at the service provider rather than at individual illegal downloaders.
The four record companies taking the action are EMI, Sony BMG, Universal Music and Warner Music.
Willie Kavanagh, Managing Director of EMI Ireland and Chairman of the Irish Recorded Music Association, said because of illegal downloading and other factors, the Irish music industry was experiencing a "dramatic and accelerating decline" in income.
He said sales in the Irish market dropped 30% in the six years up to 2007.
EMI and the other companies are challenging Eircom's refusal to use filtering technology or other measures to voluntarily block or filter illegally downloaded material.
Last October Eircom told the companies it was not in a position to use the filtering software.
Eircom also told the companies that it was not on notice of specific illegal activity which infringed the companies' rights and it had no legal obligation to monitor traffic on its network.
It's the first case to be aimed at the service provider rather than at individual illegal downloaders.
The four record companies taking the action are EMI, Sony BMG, Universal Music and Warner Music.
Willie Kavanagh, Managing Director of EMI Ireland and Chairman of the Irish Recorded Music Association, said because of illegal downloading and other factors, the Irish music industry was experiencing a "dramatic and accelerating decline" in income.
He said sales in the Irish market dropped 30% in the six years up to 2007.
EMI and the other companies are challenging Eircom's refusal to use filtering technology or other measures to voluntarily block or filter illegally downloaded material.
Last October Eircom told the companies it was not in a position to use the filtering software.
Eircom also told the companies that it was not on notice of specific illegal activity which infringed the companies' rights and it had no legal obligation to monitor traffic on its network.
Sunday, 8 June 2008
The Counterfeiters
Winner of the 2008 Academy Award for Best Foreign Language Film, Stefan Ruzowitzky's THE COUNTERFEITERS is the first film from Austria to ever receive that prestigious honor. Based on the memoir by Adolf Burger, the film tells the inspiring story of a pre-World War II criminal whose cunning and fiery spirit enable him to overcome deadly odds and survive life in Germany's Sachsenhausen concentration camp. Before the war, Salomon Sorowitsch (Karl Markovics) was one of the world's most ingenious counterfeiters, until he was finally caught and arrested by Friedrich Herzog (Devid Striesow). Years later, as the Nazi movement is in full swing, the nefariously charming Herzog--now a Nazi leader--recruits Sorowitsch to lead an enormous counterfeiting project called Operation Bernhard. Placed in a horrific position of moral corruption, Sorowitsch is forced to decide whether or not to save his own life or prevent the Nazis from causing further damage on an even grander scale. His fellow prisoner Adolf Burger (August Diehl) is determined to sabotage the operation, but Sorowitsch understands how dangerous a proposition this is.
While THE COUNTERFEITERS is based on real-life tragedy, it never loses its primary objective as a work of dramatic entertainment. This deft balancing act is what keeps Ruzowitzky's moving tale from becoming too bleak and depressing. The result is a deeply impressive work that addresses a topic not often explored in Holocaust cinema--the dilemma of victims who were forced to act immorally and illegally for the betterment of their captors. Powerfully acted by Markovics, THE COUNTERFEITERS is the type of film that the Oscars were made for.
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While THE COUNTERFEITERS is based on real-life tragedy, it never loses its primary objective as a work of dramatic entertainment. This deft balancing act is what keeps Ruzowitzky's moving tale from becoming too bleak and depressing. The result is a deeply impressive work that addresses a topic not often explored in Holocaust cinema--the dilemma of victims who were forced to act immorally and illegally for the betterment of their captors. Powerfully acted by Markovics, THE COUNTERFEITERS is the type of film that the Oscars were made for.
See Also
Friday, 30 May 2008
Culture and Don Carlos
Artist: Culture and Don Carlos
Genre(s):
Reggae
Discography:
Roots and Culture
Year: 2007
Tracks: 10
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